We examined whether ext would preserve renal hemodynamics and structure in the spontaneously hypertensive rat shr, and whether these effects were mediated by improved redox. Influence on blood pressure of renal isografts between spontaneously hypertensive and normotensive rats, utilizing the f1 hybrids. Three kinds of dipeptides, glycylsarcosine glysar, trphis, and captopril a dipeptidomimetic drug, a glysarsar tripeptide, a glysarsarsar tetrapeptide, and a glysarsarsarsar pentapeptide were administered at doses of 10 mgkg each to 8. Spontaneously hypertensive rats have more orexin neurons in their. The strokeprone spontaneously hypertensive rat shrsp is a unique genetic model of severe hypertension and cerebral stroke. Effects of silodosin and tadalafil on bladder dysfunction. In the present study, we aimed to evaluate the effect of aging on the absorption of small peptides in spontaneously hypertensive rats shrs.
Therefore, normotensive wky rats are employed as normotensive controls in studies on shrs. Spontaneously hypertensive rat an overview sciencedirect topics. The spontaneously hypertensive rat shr is the most widely used animal model of essential hypertension and accompanying metabolic disturbances. Acute treatment with lauric acid reduces blood pressure. A lightmicroscopic study of various organs of strokeprone spontaneously hypertensive shrsp rats was performed. Is cardiac hypertrophy in spontaneously hypertensive rats the. Body weight and energy balance also influence the cardiovascular system of spontaneously hypertensive rats shr. Adefect present in spontaneously hypertensive rats a possible modelofhumanessential hypertension gordonh.
The spontaneously hypertensive rat shr is the most commonly used model of hypertension and cardiovascular disease. Vascular endothelial function was examined by the relaxation of the artery in response to acetylcholine ach. Shr are the most widely used animal model to study hypertension accompanied by vascular oxidative stress 12. Apocynin influence on oxidative stress and cardiac. The combined influence of hypertension and aging had an additive detrimental effect on cognitive functions. Origin derived from a nucleus colony obtained from the national institutes of health, bethesda, maryland.
Abstractspontaneously hypertensive rats shr of 3 to 12 months of age learned and retrieved less information than normotensive. Normotensive wistarkyoto wky rats were placed on a control diet. Saltinduced hypertension in normotensive spontaneously. Twelve hours after apap administration, plasmatic levels of liver function. Light microscopic study of renal morphological alterations in spontaneously hypertensive rats article pdf available in journal of biomedical and clinical research 101.
New wistar kyoto and spontaneously hypertensive rat transgenic. Spontaneously hypertensive rat shr is an animal model of essential or primary hypertension, used to study cardiovascular disease. In the present study, spontaneously hypertensive rats shrs and wistar kyoto wky rats were exposed to hs and regularsalt rs diets for 6 weeks and fluid. Shrsp, as well as the spontaneously hypertensive rat, the parental.
In this study, the combination of metabolomics and standard biochemical and biometric parameters was used to describe the metabolic effects of dietinduced obesity and its treatment with the novel antiobesity compound palm11prrp31 palmitoylated prolactinreleasing peptide in spontaneously hypertensive rats shr and normotensive wistar kyoto rats wky. Systolic blood pressure sbp was determined by tail plethysmography. Increased motor activity is a defining characteristic of patients with adhd, and spontaneously hypertensive rats have been suggested to be an animal model of this disorder. These arterioles were frequently accompanied by occlusion of the lumen, and occasionally intracerebral hemorrhages and mincroinfarcts. Patterns of motor activity in spontaneously hypertensive. The impact of four different classes of anesthetics on the. A pathological study of the brain of the strokeprone spontaneously hypertensive shrsp rats revealed development of fibrinoid necrosis of the wall of the intracerebral arterioles. The spontaneous hypertensive rat shr has been used as a wellestablished model of genetic hypertension and age. The shr strain was produced by okamoto and aoki 1963 by selective inbreeding of wistarkyoto wky rats with high blood pressure. Representative authentic recordings of blood pressure changes in conscious wistar rats and spontaneously hypertensive rats shr during the sequential blockade of ras by captopril 10 mg. It is the most studied model of hypertension measured as number of publications. In the present study, 15weekold spontaneously hypertensive rats shr were fed diets containing 30 % ww beans, peas, lentils, chickpeas, or mixed pulses or a pulsefree control diet for 4 weeks. The japanese strains of spontaneously hypertensive rats shr are normotensive at birth but. We measured the levels of nitritenitrate no 2 no 3 anions and lipid peroxidation in asxo.
Michael wyss, sanya roysommuti, kathryn king, inga kadisha. Contribution of nitric oxide, angiotensin ii and superoxide dismutase to exerciseinduced attenuation of blood pressure elevation in spontaneously hypertensive rats. Braley, and alphonsamenachery, endocrinehypertension unit, department ofmedicine, harvardmedical school, brigham, womens hospital, boston, massachusetts 02115 abstract 30% of patients with essential hyper. Food restriction reduces sympathetic support of blood. Curcumin prevents strokes in strokeprone spontaneously.
The effects of chronic ext on the development of hypertensioninduced renal injury remain unknown. In the present study, we wanted to use linear and nonlinear methods to explore differences in motor activity patterns in shrncrl rats compared to wistar kyoto wkynhsd rats. The authors have named this wistar strain of rats with spontaneous occurrence of hypertension as spontaneously hypertensive rats okamotoaoki. Metformin improves endothelial function and reduces blood. Spontaneously hypertensive rats have more orexin neurons. Pdf on jun 1, 2008, kundu sankhanava and others published the story of spontaneously hypertensive rat shr.
Notwithstanding these deficiencies in learning and memory. Pdf interval bisection in spontaneously hypertensive. Hepatoprotective effect of silymarin silybum marianum on. Abstractspontaneously hypertensive rats shr of 3 to 12 months of age learned and retrieved less information than normotensive wistarkyoto rats wky, although no difference was found with animals from 18 and 24 months of age. Home office approval according to the animals scientific procedures act, 1986 and subsequent revisions and conformed to the guide for the care and use of laboratory animals published by the national institutes of health nih publication no. Cardiac and renal hyperplasia in newborn spontaneously. However, the role of cd36 in blood pressure regulation.
Spontaneously hypertensive rats hypertension aha journals. Pdf dietary vitamin c supplementation lowers blood. This study aimed to investigate the antihypertensive effects of p. Spontaneously hypertensive rats shrnih strain harbor a deletion variant in the cd36 fatty acid transporter and display defective fatty acid metabolism, insulin resistance and hypertension. The glymphatic system is a brainwide csf transport system that uses the perivascular space for fast inflow of csf.
The wistar kyoto wky rat and the spontaneously hypertensive shr rat inbred strains are. Naturally occurring kidney stones are rare in animals. Spontaneously hypertensive rats shr constitute a model of endothelial dysfunction involving increased production of endothelial coxderived contracting factors in a setting of ht 18, 19. Metabolomic study of obesity and its treatment with. Taconic received stock at f35 from the nih animal genetic resource in 1972. Jci erythrocytosis in spontaneously hypertensive rats. Arterial pulsations are a major driver of glymphatic csf inflow, and hypertension that causes vascular pathologies, such as arterial stiffening and perivascular alterations, may impede the inflow. Cannabinoidinduced conditioned place preference in the.
Body fluid volumes in the spontaneously hypertensive rat. The actions of antioxidant apocynin include inhibiting reactive oxygen species ros generation by nicotinamide adenine dinucleotide phosphate nadph oxidases and ros scavenging. Animals normotensive n or hypertensive shr were treated or not with apap 3 gkg, oral or previously treated with slm. Transgenic expression of cd36 in the spontaneously. Blood pressure lowering effect of cuban policosanol is. The predominant tissue alteration consisted of rarefaction and cyst formation. Brain dopamine transporter in spontaneously hypertensive rats. Genetic, physiological and comparative genomic studies of. The spontaneously hypertensive rat shr, often used to study cardiovascular disease processes, may also be utilized to model certain central nervous system. Spontaneously hypertensive rats 3monthold, n 10group received tap water shr, water containing 1.
In order to confirm the blood pressure lowering effect of policosanol in a hypertension animal model, we supplemented policosanol to spontaneously hypertensive rats shr. Lentilbased diets attenuate hypertension and largeartery. Okamoto, kyoto school of medicine, 1963, from outbred wistar kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure. Resistance training in spontaneously hypertensive rats. Development of a strain of spontaneously hypertensive rats. We studied the effects of chronic consumption of extra virgin olive oil evoo, enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in. We used dynamic contrastenhanced mri to assess the effect of hypertension. Spontaneously hypertensive rats shr and wistar kyoto rats wky were used throughout. Dietary cqa reduces oxidative stress and improves nitric oxide bioavailability by inhibiting excessive production of reactive oxygen species in the vasculature, and leads to the attenuation of endothelial dysfunction, vascular hypertrophy, and hypertension in spontaneously hypertensive rats. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. The hypotensive effect caused by intravenous infusion of hesc 0. Spontaneously hypertensive rats shr and normotensive controls wky were fed with a highcholesterol diet for 12 weeks, and endothelial function was assessed in isolated thoracic aortic rings. The spontaneously hypertensive outbred model was developed by nih in 1966 from wistar kyoto outbred stock from okamoto, kyoto school of medicine.
Kohno h, furukawa s, naito h, minamitani k, ohmori d, yamakura f. Vascular structure and oxidative stress in saltloaded. Lentilbased diets attenuate hypertension and largeartery remodelling in spontaneously hypertensive rats matthew g. Transgenic rescue of cd36 in shr ameliorates insulin resistance and improves dyslipidemia. Brain dopamine transporter in spontaneously hypertensive rats article pdf available in journal of nuclear medicine 383. Hypertension starts to develop in these rats at 56.
Discussion established hypertension in the spontaneously hypertensive rat is characterized by a normal ecfv and a lower intravascular volume than in weightmatched wistar rats. This increase in red cell count paralleled the increase in body weight and the rise in blood pressure. Antihypertensive potential and mechanism of action of. Antioxidants free fulltext antihypertensive effects.
The spontaneously hypertensive rat shr, the most widely studied model of human. Pdf light microscopic study of renal morphological. Brother x sister mating with continued selection for spontaneous hypertension was then started. Abstractspontaneously hypertensive rats shr of 3 to 12 months of age learned and retrieved less information than normotensive wistarkyoto rats wky. Although increased oxidative stress is a major component of diabetic hypertensive cardiomyopathy, research into the effects of antioxidants on cardiac remodeling remains scarce. Strokeprone spontaneously hypertensive rats shrsp were randomly divided into control group n 10 and curcumin group n 10, and saline or curcumin 100 mgkgday was administrated daily. Chlorogenic acid attenuates hypertension and improves. Recent progress in the genetics of spontaneously hypertensive rats.
Parenchymal damage of the organs, secondary to the. This study was aimed to investigate the effect of silymarin slm on the hypertension state and the liver function changes induced by acetaminophen apap in spontaneously hypertensive rat shr. Download a pdf of spontaneously hypertensive shr rats by the national research council for free. Pdf the story of spontaneously hypertensive rat shr. Exercise training ext is a recommended adjunct to many pharmaceutical antihypertensive therapies. This study evaluated the in vivo potential antihypertensive effect of hydroalcoholic extract of syzygium cumini leaves hesc in normotensive wistar rats and in spontaneously hypertensive rats shr, as well as its in vitro effect on the vascular reactivity of resistance arteries. Interval bisection in spontaneously hypertensive rats. Nutrients free fulltext cardioprotective effect of a. Taylor1,2,3 1department of physiology, university of manitoba, winnipeg, canada 2department of human nutritional sciences, university of manitoba, winnipeg, canada 3canadian centre for agrifood research in health and medicine, st. Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. Pdf hypercholesterolemia does not alter endothelial.